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. 2013 Apr 15;14(6):675-7.
doi: 10.1002/cbic.201200762. Epub 2013 Mar 25.

The mechanisms of radical SAM/cobalamin methylations: an evolving working hypothesis

K K Jason Chan  1 , Stephen Thompson, David O'Hagan
Affiliations

The mechanisms of radical SAM/cobalamin methylations: an evolving working hypothesis

K K Jason Chan et al. Chembiochem. .

Abstract

ALL ABOUT ME: Pierre and co-workers have revealed mechanistic details of a tryptophan methyltransferase (TsrM) involved in the biosynthesis of the thiopeptide antibiotic, thiostrepton. Utilising cobalamin and a [4Fe-4S] cluster to generate 2-methyltryptophan from tryptophan, a key difference between this enzyme and other radical SAM methyltransferases is that the reaction is not initiated by a single-electron reduction of SAM to generate 5'-dA⋅.

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