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. 1990 Jun;87(12):4781-4.
doi: 10.1073/pnas.87.12.4781.

The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow

I Förster  1 , K Rajewsky
Affiliations

The bulk of the peripheral B-cell pool in mice is stable and not rapidly renewed from the bone marrow

I Förster et al. Proc Natl Acad Sci U S A. 1990 Jun.

Abstract

We have reevaluated the in vivo lifespan of B lymphocytes based on incorporation of the thymidine analogue 5-bromo-2'-deoxyuridine into the DNA of dividing cells. To exclude potential alterations in the turnover of B-lineage cells due to the bromodeoxyuridine incorporation, we performed pulse-chase experiments comparing the appearance and disappearance of bromodeoxyuridine-labeled cells over long periods of time. The data consistently show that more than two-thirds of splenic B cells in adult (greater than 2 months old) mice have a lifetime of several weeks or months, whereas a more rapid turnover takes place in young (4 week old) mice. Thus, the peripheral B-cell pool is only slowly renewed after it has been initially built up early in life.

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