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Comment
. 2013 Apr 2;110(14):5279-80.
doi: 10.1073/pnas.1303297110. Epub 2013 Mar 25.

How bacteria survive an acid trip

Karan S Hingorani  1 , Lila M Gierasch
Affiliations
Comment

How bacteria survive an acid trip

Karan S Hingorani et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1.
Fig. 1.
pH-dependent activity of HdeA (in green and purple outline) allows it to have maximal chaperone activity in the low-pH environment of the stomach. Here, periplasmic proteins (example in blue) will be destabilized by the harsh acidic conditions. Binding to HdeA protects them such that they may be released for refolding upon arrival of the bacterium in the small intestine. The work of Foit et al. (2), reported in PNAS, reveals how protonation of two key aspartic acid residues shifts HdeA to a partially unfolded, chaperone-active monomeric state.
See this image and copyright information in PMC

Comment on

  • Chaperone activation by unfolding.
    Foit L, George JS, Zhang BW, Brooks CL 3rd, Bardwell JC. Foit L, et al. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):E1254-62. doi: 10.1073/pnas.1222458110. Epub 2013 Mar 4. Proc Natl Acad Sci U S A. 2013. PMID: 23487787 Free PMC article.

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