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Review
. 2013 Mar;46(3):217-26.
doi: 10.1590/1414-431x20132703. Epub 2013 Mar 15.

Impact of HPV infection on the development of head and neck cancer

J Betiol  1 , L L Villa, L Sichero
Affiliations
Review

Impact of HPV infection on the development of head and neck cancer

J Betiol et al. Braz J Med Biol Res. 2013 Mar.

Abstract

Human papillomavirus (HPV)-related head and neck squamous cell carcinoma (HNSCC) is considered to be a distinct clinical entity with better prognosis than the classical tobacco- and alcohol-associated tumors. The increasing incidence of this neoplasia during the last decades highlights the need to better understand the role of HPV in the development of these cancers. Although the proportion of HNSCC attributed to HPV varies considerably according to anatomical site, overall approximately 25% of all HNSCC are HPV-DNA positive, and HPV-16 is by far the most prevalent type. In this review we discuss the existing evidence for a causal association between HPV infection and HNSCC at diverse anatomical head and neck subsites.

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Figures

Figure 1
Figure 1. Overall HPV-DNA prevalence in head and neck squamous cell carcinomas at different anatomical subsites. Range values stratified by geographical location are shown in parentheses (Ref. 45).
See this image and copyright information in PMC

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