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Comparative Study
. 2013 May 13;54(5):3417-25.
doi: 10.1167/iovs.13-11676.

Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma

Renato Lisboa  1 , Augusto Paranhos Jr, Robert N Weinreb, Linda M Zangwill, Mauro T Leite, Felipe A Medeiros
Affiliations
Comparative Study

Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma

Renato Lisboa et al. Invest Ophthalmol Vis Sci. .

Abstract

Purpose: To compare the ability of spectral-domain optical coherence tomography (SDOCT) retinal nerve fiber layer (RNFL), optic nerve head (ONH), and macular measurements to detect preperimetric glaucomatous damage.

Methods: The study included 142 eyes from 91 patients suspected of having the disease based on the appearance of the optic disc. All eyes had normal visual fields before the imaging session. Forty-eight eyes with progressive glaucomatous damage were included in the preperimetric glaucoma group. Ninety-four eyes without any evidence of progressive glaucomatous damage and followed untreated for 12.8 ± 3.6 years were used as controls. Areas under the receiver operating characteristic curves (AUC) were calculated to summarize diagnostic accuracies of the parameters.

Results: The three RNFL parameters with the largest AUCs were average RNFL thickness (0.89 ± 0.03), inferior hemisphere average thickness (0.87 ± 0.03), and inferior quadrant average thickness (0.85 ± 0.03). The three ONH parameters with the largest AUCs were vertical cup-to-disc ratio (0.74 ± 0.04), rim area (0.72 ± 0.05), and rim volume (0.72 ± 0.05). The three macular parameters with the largest AUCs were GCC average thickness (0.79 ± 0.04), GCC inferior thickness (0.79 ± 0.05), and GCC superior thickness (0.76 ± 0.05). Average RNFL thickness performed better than vertical cup-to-disc ratio (0.89 vs. 0.74; P = 0.007) and GCC average thickness (0.89 vs. 0.79; P = 0.015).

Conclusions: SDOCT RNFL measurements performed better than ONH and macular measurements for detecting preperimetric glaucomatous damage in a cohort of glaucoma suspects. (ClinicalTrials.gov number, NCT00221897.).

Keywords: diagnosis; glaucoma; preperimetric.

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Figures

Figure 1
Figure 1
ROC curves for the three RNFL parameters with largest areas under the ROC curves: average RNFL thickness, inferior hemisphere RNFL thickness, and inferior quadrant RNFL thickness.
Figure 2
Figure 2
ROC curves the three ONH parameters with largest areas under the ROC curves: vertical cup-to-disc ratio, rim area, and rim volume.
Figure 3
Figure 3
ROC curves for the three macular parameters with largest areas under the ROC curves: GCC average thickness, GCC inferior thickness, and GCC superior thickness.
Figure 4
Figure 4
ROC curves for the parameters with largest AUCs of each protocol: inferior hemisphere RNFL thickness, vertical cup-to-disc ratio, and GCC retinal thickness.
See this image and copyright information in PMC

References

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