Comment
doi: 10.1158/1078-0432.CCR-13-0386.
Epub 2013 Mar 26.
PRAMEing a picture of differentiation therapy for AML?
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- PMID: 23532884
- DOI: 10.1158/1078-0432.CCR-13-0386
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Comment
PRAMEing a picture of differentiation therapy for AML?
Clin Cancer Res.
.
Abstract
Addition of retinoic acid to chemotherapy improves survival of patients with acute myeloid leukemia. This effect is more pronounced in leukemias that express high levels of PRAME. PRAME is an inhibitor of retinoic acid signaling, which may prove to be an important marker for retinoic acid response.
©2013 AACR.
Comment on
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PRAME-induced inhibition of retinoic acid receptor signaling-mediated differentiation--a possible target for ATRA response in AML without t(15;17).Clin Cancer Res. 2013 May 1;19(9):2562-71. doi: 10.1158/1078-0432.CCR-11-2524. Epub 2013 Feb 26. Clin Cancer Res. 2013. PMID: 23444226
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