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Review
. 2013:2013:971841.
doi: 10.1155/2013/971841. Epub 2013 Mar 5.

Low-grade inflammation and spinal cord injury: exercise as therapy?

Eduardo da Silva Alves  1 , Valdir de Aquino Lemos, Francieli Ruiz da Silva, Fabio Santos Lira, Ronaldo Vagner Thomathieli Dos Santos, João Paulo Pereira Rosa, Erico Caperuto, Sergio Tufik, Marco Tulio de Mello
Affiliations
Review

Low-grade inflammation and spinal cord injury: exercise as therapy?

Eduardo da Silva Alves et al. Mediators Inflamm. 2013.

Abstract

An increase in the prevalence of obesity in people with spinal cord injury can contribute to low-grade chronic inflammation and increase the risk of infection in this population. A decrease in sympathetic activity contributes to immunosuppression due to the lower activation of immune cells in the blood. The effects of physical exercise on inflammatory parameters in individuals with spinal cord injury have not been well described. We conducted a review of the literature published from 1974 to 2012. This review explored the relationships between low-grade inflammation, spinal cord injury, and exercise to discuss a novel mechanism that might explain the beneficial effects of exercise involving an increase in catecholamines and cytokines in people with spinal cord injury.

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