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. 2013:2013:617251.
doi: 10.1155/2013/617251. Epub 2013 Mar 4.

Linezolid is associated with serotonin syndrome in a patient receiving amitriptyline, and fentanyl: a case report and review of the literature

Lampros Samartzis  1 , Paraskevi Savvari, Sofoklis Kontogiannis, Stavros Dimopoulos
Affiliations

Linezolid is associated with serotonin syndrome in a patient receiving amitriptyline, and fentanyl: a case report and review of the literature

Lampros Samartzis et al. Case Rep Psychiatry. 2013.

Abstract

We report a unique case of an adverse interaction between the oxazolidinone antibiotic linezolid, the tricyclic antidepressant amitriptyline and the opioid analgesic fentanyl in a 68-year-old woman with advanced ischemic peripheral arterial disease and sepsis, under empirical antibiotic treatment. We also summarize the current relevant literature as identified via PubMed, EMBASE, and PsycINFO as well as reference sections of selected articles.

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