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. 2013:2013:276540.
doi: 10.1155/2013/276540. Epub 2013 Mar 6.

MicroRNAs in Cerebral Ischemia

Yang Wang  1 , Yongting Wang, Guo-Yuan Yang
Affiliations

MicroRNAs in Cerebral Ischemia

Yang Wang et al. Stroke Res Treat. 2013.

Abstract

The risk of ischemic stroke increases substantially with age, making it the third leading cause of death and the leading cause of long-term disability in the world. Numerous studies demonstrated that genes, RNAs, and proteins are involved in the occurrence and development of stroke. Current studies found that microRNAs (miRNAs or miRs) are also closely related to the pathological process of stroke. miRNAs are a group of short, noncoding RNA molecules playing important role in posttranscriptional regulation of gene expression and they have emerged as regulators of ischemic preconditioning and ischemic postconditioning. Here we give an overview of the expression and function of miRNAs in the brain, miRNAs as biomarkers during cerebral ischemia, and clinical applications and limitations of miRNAs. Future prospects of miRNAs are also discussed.

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Figures

Figure 1
Figure 1
Regulation of miRNAs in ischemic stroke. Bracket indicates reference cited.
See this image and copyright information in PMC

References

    1. Zhang C. Micrornomics: a newly emerging approach for disease biology. Physiological Genomics. 2008;33(2):139–147. - PubMed
    1. Jeyaseelan K, Lim KY, Armugam A. MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion. Stroke. 2008;39(3):959–966. - PubMed
    1. Kloosterman WP, Plasterk RHA. The diverse functions of MicroRNAs in animal development and disease. Developmental Cell. 2006;11(4):441–450. - PubMed
    1. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nature Reviews Cancer. 2006;6(11):857–866. - PubMed
    1. Hernando E. microRNAs and cancer: role in tumorigenesis, patient classification and therapy. Clinical and Translational Oncology. 2007;9(3):155–160. - PubMed

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