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Case Reports
. 2013 Jun;51(6):1769-73.
doi: 10.1128/JCM.00435-13. Epub 2013 Mar 27.

Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera

Yvonne Achermann  1 , Matthias Rössle, Matthias Hoffmann, Vanessa Deggim, Stefan Kuster, Dieter R Zimmermann, Guido Bloemberg, Michael Hombach, Barbara Hasse
Affiliations
Case Reports

Prosthetic valve endocarditis and bloodstream infection due to Mycobacterium chimaera

Yvonne Achermann et al. J Clin Microbiol. 2013 Jun.

Abstract

Prosthetic valve endocarditis (PVE) due to fast-growing nontuberculous mycobacteria (NTM) has been reported anecdotally. Reports of PVE with slowly growing NTM, however, are lacking. We present here one case of PVE and one case of bloodstream infection caused by Mycobacterium chimaera. Randomly amplified polymorphic DNA (RAPD)-PCR indicated a relatedness of the two M. chimaera strains. Both patients had heart surgery 2 years apart from each other. A nosocomial link was not detected.

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Figures

Fig 1
Fig 1
Histopathological analysis of valve tissue from patient 1. (a) Overview of the necrotic valve tissue (*) with granulocytic demarcation (arrows) and foamy macrophages (arrowheads) (hematoxylin and eosin [H&E] stain); (b) swollen foamy macrophages (H&E stain); (c) presence of numerous acid-fast bacilli (Ziehl-Neelsen stain).
Fig 2
Fig 2
Mycobacterium chimaera strain typing using randomly amplified polymorphic DNA (RAPD)-PCR. Shown are RAPD-PCR patterns of M. chimaera clinical isolates from the two patients (lane 1, patient 1; lane 2, patient 2) and of eight respiratory culture isolates from eight different patients (lanes 3 to 10). RAPD-PCR patterns were generated with primers IS986-FP (A) and OPA18 (B). MW, molecular weight marker.
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