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. 2013 Jul;36(7):2038-40.
doi: 10.2337/dc12-2465. Epub 2013 Mar 27.

Fasting plasma glucose at 24-28 weeks to screen for gestational diabetes mellitus: new evidence from China

Wei-wei Zhu  1 , Ling Fan, Hui-xia Yang, Ling-ying Kong, Shi-ping Su, Zi-lian Wang, Ya-Li Hu, Mei-hua Zhang, Li-Zhou Sun, Yang Mi, Xiu-ping Du, Hua Zhang, Yun-hui Wang, Yin-ping Huang, Li-ruo Zhong, Hai-rong Wu, Nan Li, Yun-feng Wang, Anil Kapur
Affiliations

Fasting plasma glucose at 24-28 weeks to screen for gestational diabetes mellitus: new evidence from China

Wei-wei Zhu et al. Diabetes Care. 2013 Jul.

Abstract

Objective: To evaluate the usefulness of a fasting plasma glucose (FPG) at 24-28 weeks' gestation to screen for gestational diabetes mellitus (GDM).

Research design and methods: The medical records and results of a 75-g 2-h oral glucose tolerance test (OGTT) of 24,854 pregnant women without known pre-GDM attending prenatal clinics in 15 hospitals in China were examined.

Results: FPG cutoff value of 5.1 mmol/L identified 3,149 (12.1%) pregnant women with GDM. FPG cutoff value of 4.4 mmol/L ruled out GDM in 15,369 (38.2%) women. With use of this cutoff point, 12.2% of patients with mild GDM will be missed. The positive predictive value is 0.322, and the negative predictive value is 0.928.

Conclusions: FPG at 24-28 weeks' gestation could be used as a screening test to identify GDM patients in low-resource regions. Women with an FPG between ≥4.4 and ≤5.0 mmol/L would require a 75-g OGTT to diagnose GDM. This would help to avoid approximately one-half (50.3%) of the formal 75-g OGTTs in China.

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References

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