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Comparative Study
. 2013 Mar 28:12:55.
doi: 10.1186/1475-2840-12-55.

Sagittal abdominal diameter is a more independent measure compared with waist circumference to predict arterial stiffness in subjects with type 2 diabetes--a prospective observational cohort study

Elsa M Dahlén  1 , Niclas Bjarnegård, Toste Länne, Fredrik H Nystrom, Carl J Ostgren
Affiliations
Comparative Study

Sagittal abdominal diameter is a more independent measure compared with waist circumference to predict arterial stiffness in subjects with type 2 diabetes--a prospective observational cohort study

Elsa M Dahlén et al. Cardiovasc Diabetol. .

Abstract

Background: Anthropometric measurements are useful in clinical practice since they are non-invasive and cheap. Previous studies suggest that sagittal abdominal diameter (SAD) may be a better measure of visceral fat depots. The aim of this study was to prospectively explore and compare how laboratory and anthropometric risk markers predicted subclinical organ damage in 255 patients, with type 2 diabetes, after four years.

Methods: Baseline investigations were performed in 2006 and were repeated at follow-up in 2010. Carotid intima-media thickness (IMT) was evaluated by ultrasonography and aortic pulse wave velocity (PWV) was measured with applanation tonometry over the carotid and femoral arteries at baseline and at follow-up in a cohort of subjects with type 2 diabetes aged 55-65 years old.

Results: There were significant correlations between apolipoprotein B (apoB) (r = 0.144, p = 0.03), C - reactive protein (CRP) (r = 0.172, p = 0.009) at baseline and IMT measured at follow-up. After adjustment for sex, age, treatment with statins and Hba1c, the associations remained statistically significant. HbA1c, total cholesterol or LDL-cholesterol did not correlate to IMT at follow-up. Baseline body mass index (BMI) (r = 0.130, p = 0.049), waist circumference (WC) (r = 0.147, p = 0.027) and sagittal Abdominal Diameter (SAD) (r = 0.184, p = 0.007) correlated to PWV at follow-up. Challenged with sex, SBP and HbA1c, the association between SAD, not WC nor BMI, and PWV remained statistically significant (p = 0.036). In a stepwise linear regression, entering both SAD and WC, the association between SAD and PWV was stronger than the association between WC and PWV.

Conclusions: We conclude that apoB and CRP, but not LDL-cholesterol predicted subclinical atherosclerosis. Furthermore, SAD was more independent in predicting arterial stiffness over time, compared with WC, in middle-aged men and women with type 2 diabetes.

Trial registration: ClinicalTrials.gov NCT01049737.

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Figures

Figure 1
Figure 1
Correlation between baseline characteristics 2006 and IMT and PWV 2010. LDL; low-density lipoprotein, nonHDL; non high-density lipoprotein, apoB; apolipoprotein B, CRP; c-reactive protein, SBP; systolic blood pressure, BMI; body mass index; SAD; sagittal abdominal diameter, WC; waist circumference. * Correlation significant at p < 0.05, ** correlation significant at p < 0.01.
Figure 2
Figure 2
Relation between changes in SAD (x-axis) and WC (y-axis) after 4 years from the baseline investigation both measured in cm.
See this image and copyright information in PMC

References

    1. Knowles KM, Paiva LL, Sanchez SE, Revilla L, Lopez T, Yasuda MB, Yanez ND, Gelaye B, Williams MA. Waist Circumference, Body Mass Index, and Other Measures of Adiposity in Predicting Cardiovascular Disease Risk Factors among Peruvian Adults. Int J Hypertens. 2011;2011:931402. - PMC - PubMed
    1. Petersson H, Daryani A, Riserus U. Sagittal abdominal diameter as a marker of inflammation and insulin resistance among immigrant women from the Middle East and native Swedish women: a cross-sectional study. Cardiovasc Diabetol. 2007;6:10. doi: 10.1186/1475-2840-6-10. - DOI - PMC - PubMed
    1. Riserus U, Arnlov J, Brismar K, Zethelius B, Berglund L, Vessby B. Sagittal abdominal diameter is a strong anthropometric marker of insulin resistance and hyperproinsulinemia in obese men. Diabetes Care. 2004;27(8):2041–2046. doi: 10.2337/diacare.27.8.2041. - DOI - PubMed
    1. Gustat J, Elkasabany A, Srinivasan S, Berenson GS. Relation of abdominal height to cardiovascular risk factors in young adults: the Bogalusa heart study. Am J Epidemiol. 2000;151(9):885–891. doi: 10.1093/oxfordjournals.aje.a010292. - DOI - PubMed
    1. Ohrvall M, Berglund L, Vessby B. Sagittal abdominal diameter compared with other anthropometric measurements in relation to cardiovascular risk. Int J Obes Relat Metab Disord. 2000;24(4):497–501. doi: 10.1038/sj.ijo.0801186. - DOI - PubMed

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