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. 2013 May 30;212(2):161-3.
doi: 10.1016/j.pscychresns.2013.01.006. Epub 2013 Mar 29.

Abnormal fusiform activation during emotional-face encoding assessed with functional magnetic resonance imaging

Nancy E Adleman  1 , Reilly R Kayser, Aviva K Olsavsky, Brian L Bones, Eli J Muhrer, Stephen J Fromm, Daniel S Pine, Carlos Zarate, Ellen Leibenluft, Melissa A Brotman
Affiliations

Abnormal fusiform activation during emotional-face encoding assessed with functional magnetic resonance imaging

Nancy E Adleman et al. Psychiatry Res. .

Abstract

This functional magnetic resonance imaging study shows that children and adults with bipolar disorder (BD), compared with healthy subjects, exhibit impaired memory for emotional faces and abnormal fusiform activation during encoding. Fusiform activation abnormalities in BD were correlated with mania severity and may therefore represent a trait and state BD biomarker.

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Figures

Fig1
Fig1
Condition (successfully-encoded faces, forgotten faces) by diagnosis interaction in right fusiform gyrus (A), due to greater activation for Hit vs. Fixation than Miss vs. Fixation in healthy volunteers (HV), while subjects with bipolar disorder (BD) exhibited the opposite pattern (B). Percent signal averaged across entire cluster (k=25 voxels; cluster peak MNI coordinates: 24, -86, -2). **p<0.01; *p<0.05.
See this image and copyright information in PMC

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