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. 2013 May;76(1):119-21.
doi: 10.1016/j.diagmicrobio.2013.02.030. Epub 2013 Mar 27.

A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem

Norifumi Shigemoto  1 , Shizuo Kayama, Ryuichi Kuwahara, Junzo Hisatsune, Fuminori Kato, Hisaaki Nishio, Katsutoshi Yamasaki, Yasunao Wada, Taijiro Sueda, Hiroki Ohge, Motoyuki Sugai
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A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem

Norifumi Shigemoto et al. Diagn Microbiol Infect Dis. 2013 May.

Abstract

We investigated 5 metallo-β-lactamase (MBL)-positive Klebsiella isolates from Japan showing intermediate resistance to imipenem. Sequencing of the MBL gene identified a novel variant of IMP-1 with a single amino acid substitution, Glu87Gly. This variant is designated as IMP-34 where blaIMP-34 is located on a transmissible plasmid.

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