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. 2013 Mar 28;2013(3):CD004559.
doi: 10.1002/14651858.CD004559.pub4.

Chinese medicinal herbs for influenza

Lanhui Jiang  1 , Linyu Deng, Taixiang Wu
Affiliations

Chinese medicinal herbs for influenza

Lanhui Jiang et al. Cochrane Database Syst Rev. .

Abstract

Background: Influenza is a communicable acute respiratory infection which, during epidemics, can cause high morbidity and mortality rates. Traditional Chinese medicinal herbs, often administered following a particular Chinese medical theory, may be a potential treatment of choice.

Objectives: To assess the effect of Chinese medicinal herbs used to prevent and treat influenza and to estimate the frequency of adverse effects.

Search methods: We searched CENTRAL (2012, Issue 11), MEDLINE (January 1966 to November week 2, 2012), EMBASE (January 1988 to November 2012) and CNKI (January 1988 to 29 March 2012). We also searched reference lists of articles and the WHO ICTRP search portal (November 2012).

Selection criteria: Randomised controlled trials (RCTs) comparing traditional Chinese medicinal herbs with placebo, no treatment or conventional medicine normally used in preventing and treating uncomplicated influenza.

Data collection and analysis: Two review authors independently extracted data and assessed trial quality.

Main results: We included 18 studies involving 2521 participants. The methodological quality of 17 included studies was poor. Included RCTs separately compared medicinal herbs with different antiviral drugs, precluding any pooling of results. Only three indicated that compared with antiviral drugs, Chinese medicinal herbs may be effective in preventing influenza and alleviating influenza symptoms. 'Ganmao' capsules were found to be more effective than amantadine in decreasing influenza symptoms and speeding recovery in one study (in which adverse reactions were mentioned in the amantadine group although no data were reported). There were no significant differences between 'E Shu You' and ribavirin in treating influenza, nor in the occurrence of adverse reactions. Ten studies reported mild adverse reactions.

Authors' conclusions: Most Chinese medical herbs in the included studies showed similar effects to antiviral drugs in preventing or treating influenza. Few were shown to be superior to antiviral drugs. No obvious adverse events were reported in the included studies. However, current evidence remains weak due to methodological limitations of the trials. More high-quality RCTs with larger numbers of participants and clear reporting are needed.

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Conflict of interest statement

None known.

Figures

1
1
Study flow diagram.
2
2
'Risk of bias' graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
'Risk of bias' summary: review authors' judgements about each risk of bias item for each included study.
1.1
1.1. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 1 Recovery.
1.2
1.2. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 2 Time to fever clearance.
1.3
1.3. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 3 Duration of cough.
1.4
1.4. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 4 Time to remission of muscle pain.
1.5
1.5. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 5 Time to symptom remission.
1.6
1.6. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 6 Time to remission of sore throat.
1.7
1.7. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 7 Length of hospital stay.
1.8
1.8. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 8 No improvement or worsening influenza.
1.9
1.9. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 9 Partial improvement.
1.10
1.10. Analysis
Comparison 1 Traditional Chinese medicine (TCM) versus other treatments, Outcome 10 Adverse events.
See this image and copyright information in PMC

Update of

References

References to studies included in this review

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Xu 2001 {published data only}
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Yang 2000a {published data only}
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Yang 2000b {published data only}
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Yang 2005a {published data only}
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Yao 2003 {published data only}
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Zhang 2002 {published data only}
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Zhang 2005 {published data only}
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Zhao 2006 {published data only}
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Zheng 2010 {published data only}
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Zhong 2005 {published data only}
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Zhou 2010 {published data only}
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References to studies awaiting assessment

Qiu 1997 {published data only}
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