No association between MTHFR C677T and serum uric acid levels among Japanese with ABCG2 126QQ and SLC22A12 258WW
- PMID: 23544272
- PMCID: PMC4345702
No association between MTHFR C677T and serum uric acid levels among Japanese with ABCG2 126QQ and SLC22A12 258WW
Abstract
Several genome-wide association studies (GWAS) have revealed that single nucleotide polymorphisms (SNPs) of ABCG2 and SLC22A12 were strongly associated with serum uric acid (SUA), but those of methylene tetrahydrofolate reductase (MTHFR) were not. However, there were several studies indicating the association with MTHFR C677T polymorphism. This study examined the association with the polymorphism, taking into account the genotypes of ABCG2 Q126X and SLC22A12 W258X. Subjects were 5,028 health checkup examinees of Seirei Preventive Health Care Center (3,416 males and 1,612 females) aged 35 to 69 years, who participated in the Japan Multi-Institutional Collaborative Cohort Study (J-MICC Study). Hyperuricemia was defined as SUA equal to 7 mg/dL or over. The genotype frequency was 35.9% for CC, 48.1% for CT, and 16.0% for TT, being in Hardy-Weinberg equilibrium (p=0.90). Among 4,425 participants with ABCG2 126QQ and SLC22A12 258WW who were not under medication for hyperuricemia, the mean SUA was 5.6 mg/dL, 5.6 mg/dL, and 5.7 mg/dL, respectively. When 114 participants with ABCG2 126QQ and SLC22A12 258WW under medication for hyperuricemia were included in hyperuricemia cases, the sex-age adjusted odds ratio (OR) of hyperuricemia was not significant; OR=1.00 (95% confidence interval, 0.89-1.24) for CT genotype and OR=0.98 (0.84-1.32) for TT genotype, relative to CC genotype. The present study indicated no association between SUA and MTHFR C677T genotype, after the influences of ABCG2 Q126X and SLC22A12 W258X were removed.
Similar articles
-
Serum uric acid distribution according to SLC22A12 W258X genotype in a cross-sectional study of a general Japanese population.BMC Med Genet. 2011 Mar 2;12:33. doi: 10.1186/1471-2350-12-33. BMC Med Genet. 2011. PMID: 21366895 Free PMC article.
-
Prevalence of hyperuricemia among the Chinese population of the southeast coastal region and association with single nucleotide polymorphisms in urate‑anion exchanger genes: SLC22A12, ABCG2 and SLC2A9.Mol Med Rep. 2018 Sep;18(3):3050-3058. doi: 10.3892/mmr.2018.9290. Epub 2018 Jul 16. Mol Med Rep. 2018. PMID: 30015934
-
ABCG2 rs2231142 variant in hyperuricemia is modified by SLC2A9 and SLC22A12 polymorphisms and cardiovascular risk factors in an elderly community-dwelling population.BMC Med Genet. 2020 Mar 17;21(1):54. doi: 10.1186/s12881-020-0987-4. BMC Med Genet. 2020. PMID: 32183743 Free PMC article.
-
[Uric Acid Metabolism, Uric Acid Transporters and Dysuricemia].Yakugaku Zasshi. 2024;144(6):659-674. doi: 10.1248/yakushi.23-00217. Yakugaku Zasshi. 2024. PMID: 38825475 Review. Japanese.
-
The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis.BMC Med Genet. 2020 Oct 21;21(1):210. doi: 10.1186/s12881-020-01147-2. BMC Med Genet. 2020. PMID: 33087043 Free PMC article.
Cited by
-
The Different Relationship between Homocysteine and Uric Acid Levels with Respect to the MTHFR C677T Polymorphism According to Gender in Patients with Cognitive Impairment.Nutrients. 2020 Apr 19;12(4):1147. doi: 10.3390/nu12041147. Nutrients. 2020. PMID: 32325916 Free PMC article.
References
-
- Saag KG, Mikuls TR. Recent advances in the epidemiology of gout. Curr Rheumatol Rep, 2005; 7: 235–241. - PubMed
-
- Weaver AL. Epidemiology of gout. Cleve Clin J Med, 2008; 75 Suppl 5: S9–S12. - PubMed
-
- Doherty M. New insights into the epidemiology of gout. Rheumatology, 2009; 48: ii2–ii8. - PubMed
-
- Whitfield JB, Martin NG. Inheritance and alcohol as factors influencing plasma uric acid levels. Acta Genet Med Gemellol (Roma), 1983; 32: 117–126. - PubMed
-
- Kamatani Y, Matsuda K, Okada Y Kubo M, Hosono N, Daigo Y, Nakamura Y, Kamatani N. Genome-wide association study of hematological and biochemical traits in a Japanese population. Nat Genet, 2010; 42: 210–216. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources