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Review
. 2013 Apr 1;3(4):a014019.
doi: 10.1101/cshperspect.a014019.

Model systems for cardiovascular regenerative biology

Jessica C Garbern  1 , Christine L Mummery, Richard T Lee
Affiliations
Review

Model systems for cardiovascular regenerative biology

Jessica C Garbern et al. Cold Spring Harb Perspect Med. .

Abstract

There is an urgent clinical need to develop new therapeutic approaches to treat heart failure, but the biology of cardiovascular regeneration is complex. Model systems are required to advance our understanding of biological mechanisms of cardiac regeneration as well as to test therapeutic approaches to regenerate tissue and restore cardiac function following injury. An ideal model system should be inexpensive, easily manipulated, easily reproducible, physiologically representative of human disease, and ethically sound. In this review, we discuss computational, cell-based, tissue, and animal models that have been used to elucidate mechanisms of cardiovascular regenerative biology or to test proposed therapeutic methods to restore cardiac function following disease or injury.

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Figures

Figure 1.
Figure 1.
Schematic of model systems for cardiovascular regeneration.
See this image and copyright information in PMC

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