Therapeutic potential of SIGIRR in systemic lupus erythematosus
- PMID: 23546688
- DOI: 10.1007/s00296-013-2733-0
Therapeutic potential of SIGIRR in systemic lupus erythematosus
Abstract
Single immunoglobulin IL-1-related receptor (SIGIRR), which is also known as Toll/interleukin-1 receptor 8, is a member of the interleukin-1 receptor (IL-1R) family. Different from other typical IL-1R superfamily members, SIGIRR seems to exert negatively modulates in immune responses. Several previous studies demonstrated that SIGIRR influences chronic inflammatory or autoimmune diseases, such as intestinal inflammation, rheumatoid arthritis and psoriatic arthritis. Recent work has explored the role of SIGIRR in systemic lupus erythematosus (SLE), for example, the role of SIGIRR protects the mice from hydrocarbon oil-induced lupus has been reported. These results indicate that SIGIRR may represent a novel target for the treatment of SLE. In this review, we will discuss the SIGIRR and the therapeutic potential of modulating the pathway in SLE.
Similar articles
-
The decreased frequency of SIGIRR-positive CD4+ T cells in peripheral blood of patients with SLE and its correlation with disease activity.Mol Biol Rep. 2015 Feb;42(2):423-30. doi: 10.1007/s11033-014-3783-4. Epub 2014 Oct 7. Mol Biol Rep. 2015. PMID: 25287661
-
SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.Arthritis Rheum. 2010 Aug;62(8):2249-61. doi: 10.1002/art.27517. Arthritis Rheum. 2010. PMID: 20506350
-
Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced lupus nephritis.J Pathol. 2010 Apr;220(5):596-607. doi: 10.1002/path.2678. J Pathol. 2010. PMID: 20112371
-
SIGIRR: An Orphan Receptor Mediating Anti-inflammatory Actions.Expert Rev Mol Med. 2025 Jun 30;27:e24. doi: 10.1017/erm.2025.10009. Expert Rev Mol Med. 2025. PMID: 40583347 Free PMC article. Review.
-
Interleukin-21 as a potential therapeutic target for systemic lupus erythematosus.Mol Biol Rep. 2011 Aug;38(6):4077-81. doi: 10.1007/s11033-010-0527-y. Epub 2010 Nov 24. Mol Biol Rep. 2011. PMID: 21107711 Review.
Cited by
-
Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis.Biomed Res Int. 2021 May 7;2021:6683148. doi: 10.1155/2021/6683148. eCollection 2021. Biomed Res Int. 2021. PMID: 34036103 Free PMC article.
-
Potential roles of nucleotide-binding oligomerization domain 2 in the pathogenesis of systemic lupus erythematosus.Rheumatol Int. 2014 Oct;34(10):1339-44. doi: 10.1007/s00296-014-2975-5. Epub 2014 Mar 6. Rheumatol Int. 2014. PMID: 24599604 Review.
-
Emerging role of SIGIRR rs7396562(T/G) polymorphism in systemic lupus erythematosus in a Chinese population.Inflammation. 2014 Oct;37(5):1847-51. doi: 10.1007/s10753-014-9916-z. Inflammation. 2014. PMID: 24826913
-
Increased ratio of Th17 cells to SIGIRR+CD4+ T cells in peripheral blood of patients with SLE is associated with disease activity.Biomed Rep. 2018 Oct;9(4):339-344. doi: 10.3892/br.2018.1139. Epub 2018 Aug 3. Biomed Rep. 2018. PMID: 30233787 Free PMC article.
-
SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis.Mol Med. 2022 Nov 18;28(1):135. doi: 10.1186/s10020-022-00563-9. Mol Med. 2022. PMID: 36401167 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
