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. 2013;35(4):421-34.
doi: 10.1080/13803395.2013.783000. Epub 2013 Apr 3.

The aggregate effects of multiple comorbid risk factors on cognition among HIV-infected individuals

Sapna M Patel  1 , April D Thames, Natalie Arbid, Stella E Panos, Steven Castellon, Charles H Hinkin
Affiliations

The aggregate effects of multiple comorbid risk factors on cognition among HIV-infected individuals

Sapna M Patel et al. J Clin Exp Neuropsychol. 2013.

Abstract

This study developed and then cross-validated a novel weighting algorithm based on multiple comorbid risk factors (stimulant use, vascular disease, hepatitis C, HIV disease severity, cognitive reserve) to predict cognitive functioning among 366 HIV+ adults. The resultant "risk severity score" was used to differentially weight, as a function of age, the impact and magnitude of multiple risk factors on cognition. Among older adults (≥50 years) the risk severity index was differentially predictive of learning/memory and verbal fluency, whereas among younger adults it was linked to working memory and executive function. Cognitive reserve was found to be the most robust predictor of neurocognition.

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