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Comment
. 2013 Apr;15(4):347-8.
doi: 10.1038/ncb2722.

Cullin' PLK1 from kinetochores

Colleen A McGourty  1 , Michael Rape
Affiliations
Comment

Cullin' PLK1 from kinetochores

Colleen A McGourty et al. Nat Cell Biol. 2013 Apr.

Abstract

To ensure proper attachment of all chromosomes to the spindle, PLK1 has to associate with kinetochores during prometaphase and must be released from these sites before sister chromatid separation can begin. The monoubiquitylation of PLK1 by the ubiquitin ligase CUL3-KLHL22 is now identified as a critical step in promoting the release of PLK1 from kinetochores, pushing non-proteolytic ubiquitylation into the limelight of cell division research.

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Comment on

  • Ubiquitylation-dependent localization of PLK1 in mitosis.
    Beck J, Maerki S, Posch M, Metzger T, Persaud A, Scheel H, Hofmann K, Rotin D, Pedrioli P, Swedlow JR, Peter M, Sumara I. Beck J, et al. Nat Cell Biol. 2013 Apr;15(4):430-9. doi: 10.1038/ncb2695. Epub 2013 Mar 3. Nat Cell Biol. 2013. PMID: 23455478 Free PMC article.

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