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Case Reports
. 2013 Feb;23(1):105-8.

Generalized lymphadenopathy in infancy; a case report

Mamishi Setareh  1 , Movahedi Zahra, Mohammadzadeh Vahid, Sabouni Farah
Affiliations
Case Reports

Generalized lymphadenopathy in infancy; a case report

Mamishi Setareh et al. Iran J Pediatr. 2013 Feb.

Abstract

Background: Rosai-Dorfman disease (RDD) is a rare disease of histiocytic cells, a cause of benign cervical lymphadenopathy (LAP) and massive generalized lymph node enlargement in children and adults. There are also some reports on involvement of other human body organs with or without LAP.

Case presentation: A 7-month-old infant with chief complaint of generalized massive LAP was referred to our center. RDD was diagnosed according to clinical manifestations and confirmed through histopathologic and immunoreactivity study on the obtained sample by cervical lymph node biopsy.

Conclusion: RDD is not a malignant illness and lymph node enlargement most often decreases in its size happens without special treatment.

Keywords: Generalized Lymphadenopathy; Histiocytosis; Infant; Rosai-Dorfman Disease.

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Figures

Fig. 1
Fig. 1
Cervical, axillary and inguinal lymphadenopathy
Fig. 2
Fig. 2
Emperipolesis of lymphocytes
See this image and copyright information in PMC

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