Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Apr;4(4):248-50.
doi: 10.1007/s13238-013-2841-3.

The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease

Zhilin Ren  1 , Liming Yan, Ning Zhang, Yu Guo, Cheng Yang, Zhiyong Lou, Zihe Rao
Affiliations

The newly emerged SARS-like coronavirus HCoV-EMC also has an "Achilles' heel": current effective inhibitor targeting a 3C-like protease

Zhilin Ren et al. Protein Cell. 2013 Apr.
No abstract available

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Anand K, Palm GJ, Mesters JR, Siddell SG, Ziebuhr J, et al. Structure of coronavirus main proteinase reveals combination of a chymotrypsin fold with an extra alpha-helical domain. EMBO J. 2002;21:3213–3224. doi: 10.1093/emboj/cdf327. - DOI - PMC - PubMed
    1. Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R. Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs. Science. 2003;300:1763–1767. doi: 10.1126/science.1085658. - DOI - PubMed
    1. Lau SK, Li KS, Tsang AK, Shek CT, Wang M, et al. Recent transmission of a novel alphacoronavirus, bat coronavirus HKU10, from Leschenault’s Rousettes to Pomona leaf-nosed bats: first evidence of interspecies transmission of coronavirus between bats of different suborders. J Virol. 2012;86:11906–11918. doi: 10.1128/JVI.01305-12. - DOI - PMC - PubMed
    1. Lee CC, Kuo CJ, Ko TP, Hsu MF, Tsui YC, et al. Structural basis of inhibition specificities of 3C and 3C-like proteases by zinc-coordinating and pepti-domimetic compounds. J Biol Chem. 2009;284:7646–7655. doi: 10.1074/jbc.M807947200. - DOI - PMC - PubMed
    1. Li S, Zhao Q, Zhang Y, Zhang Y, Bartlam M, et al. New nsp8 isoform suggests mechanism for tuning viral RNA synthesis. Protein Cell. 2010;1:198–204. doi: 10.1007/s13238-010-0028-8. - DOI - PMC - PubMed

Publication types

MeSH terms