Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 May 1;54(3):567-71.
doi: 10.3349/ymj.2013.54.3.567.

Association between cerebrospinal fluid S100B protein and neuronal damage in patients with central nervous system infections

Jeong-Wook Park  1 , Gyoung Im Suh, Hae-Eun Shin
Affiliations

Association between cerebrospinal fluid S100B protein and neuronal damage in patients with central nervous system infections

Jeong-Wook Park et al. Yonsei Med J. .

Abstract

Purpose: S100B protein is widely used as a measure of glial activity or damage in several brain conditions. Central nervous system (CNS) infections can cause neurological sequelae because of parenchyma invasion. It is difficult to predict further neuronal damage in the CNS infection. The present study is aimed to evaluate the role of the cerebrospinal fluid (CSF) S100B protein as an indicator of neuronal damage in CNS infection.

Materials and methods: We measured the concentration of CSF S100B protein in 62 patients with a CNS infection using an Enzyme-Linked Immunosorbent Assay. The patients with CNS infections were classified as having no neuronal damage (CNS-N) or as having neuronal damage (CNS+N) according to the presence of neurological change or structural lesions on brain MRI.

Results: The CSF S100B protein level of the CNS+N group (n=22, 0.235 μg/L, 0.10-2.18) was significantly higher than that of the CNS-N group (n=40, 0.087 μg/L, 0.06-0.12) and control group (n=40, 0.109 μg/L, 0.07-0.14, p<0.01). Using an arbitrary cut off value, S100B-positive CSF was detected in 2.5% of the CNS-N group and in 50% of the CNS+N group (p<0.05).

Conclusion: These findings suggest that increased S100B protein levels in the CSF may be associated with the neuronal damage following CNS infections.

Keywords: CNS infections; S100B protein; neuronal damage.

PubMed Disclaimer

Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
The scatter distributions of CSF S100B levels in CNS-N, CNS+N, and control groups. Horizontal bars represent median values of each group. CSF, cerebrospinal fluid; CNS, central nervous system.
Fig. 2
Fig. 2
Box plot of CSF S100B levels in the control group and in patients with viral, bacterial, and tuberculous CNS infections. The white line in the middle of the box represents median value. The box extends from the 25th to the 75th percentile. The whiskers extending from the box represent the 10th and 90th percentiles. Circles represent individual patient levels that extend above the 90th percentile. CSF, cerebrospinal fluid; CNS, central nervous system.
See this image and copyright information in PMC

References

    1. van de Beek D, Schmand B, de Gans J, Weisfelt M, Vaessen H, Dankert J, et al. Cognitive impairment in adults with good recovery after bacterial meningitis. J Infect Dis. 2002;186:1047–1052. - PubMed
    1. Schmidt H, Heimann B, Djukic M, Mazurek C, Fels C, Wallesch CW, et al. Neuropsychological sequelae of bacterial and viral meningitis. Brain. 2006;129(Pt 2):333–345. - PubMed
    1. Kim MA, Park KM, Kim SE, Oh MK. Acute symptomatic seizures in CNS infection. Eur J Neurol. 2008;15:38–41. - PubMed
    1. Rufa A, Cerase A, Annunziata P, De Santi L, Buccoliero R, Monti L, et al. Transient supranuclear paresis of the abduction in viral encephalitis of the brainstem. Neurol Sci. 2010;31:653–655. - PubMed
    1. de Louvois J, Halket S, Harvey D. Effect of meningitis in infancy on school-leaving examination results. Arch Dis Child. 2007;92:959–962. - PMC - PubMed

Substances