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. 2013 Apr 18;368(16):1560-2.
doi: 10.1056/NEJMc1215691. Epub 2013 Apr 3.

Pneumonia from human coronavirus in a macaque model

Vincent J Munster, Emmie de Wit, Heinz Feldmann

Pneumonia from human coronavirus in a macaque model

Vincent J Munster et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Radiographic and Histopathological Findings and Viral Loads in Lungs of Rhesus Macaques Inoculated with hCoV-EMC/2012
Panel A shows ventrodorsal thoracic radiographs taken before inoculation and 1, 3, and 6 days after inoculation with hCoV-EMC/2012. The circled areas are regions of interstitial infiltrates indicative of viral pneumonia. Panel B shows a view of the ventral lung of an infected animal obtained on autopsy on day 3 after inoculation, showing both normal and affected tissue. Panel C shows histopathological analysis of lung tissue collected on day 3 after inoculation, with infiltrating neutrophils and macrophages associated with acute interstitial pneumonia (arrows; hematoxylin and eosin). Panel D shows viral loads in right and left upper, middle, and lower lung lobes on day 3 (left) and 6 (right) after inoculation. After the collection of lung samples, tissues were homogenized, RNA was extracted, and quantitative reverse-transcriptase–polymerase-chain-reaction analysis was performed. Log10 equivalents of 50% tissue-culture infective doses (TCID50 eq) were calculated per gram of tissue. Each bar represents one animal.
See this image and copyright information in PMC

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Publication types