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Review
. 2013 Mar-Apr;26(2):84-91.
doi: 10.1111/dth.12025.

Understanding the pathophysiology of itch

Lilit Garibyan  1 , Curtis G Rheingold, Ethan A Lerner
Affiliations
Review

Understanding the pathophysiology of itch

Lilit Garibyan et al. Dermatol Ther. 2013 Mar-Apr.

Abstract

Itch is the most common symptom described by our patients. Treating this symptom can be challenging. A revolution is ongoing in understanding the pathophysiology of itch and will allow this challenge to be met. The present authors review and update the current understanding of the pathophysiology of itch.

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Figures

FIG. 1
FIG. 1
Itch pathway from the skin to the brain.
FIG. 2
FIG. 2
Molecular anatomy of itch. Channels and receptors on the surface of keratinocytes and nerve fibers respond to various mediators. Several examples are provided. The mechanisms by which keratinocytes and neurons communicate with each other are under investigation. DRG, dorsal root ganglia; IL-31, dorsal root ganglia; GPCR, G-protein coupled receptor; TRP, transient receptor potential.
See this image and copyright information in PMC

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