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Controlled Clinical Trial
. 2013 Jul;70(1):45-53.
doi: 10.1111/aji.12117. Epub 2013 Apr 1.

Serum proinflammatory cytokine responses to influenza virus vaccine among women during pregnancy versus non-pregnancy

Lisa M Christian  1 , Kyle Porter, Erik Karlsson, Stacey Schultz-Cherry, Jay D Iams
Affiliations
Controlled Clinical Trial

Serum proinflammatory cytokine responses to influenza virus vaccine among women during pregnancy versus non-pregnancy

Lisa M Christian et al. Am J Reprod Immunol. 2013 Jul.

Abstract

Objective: This study aimed to comprehensively describe inflammatory responses to trivalent influenza virus vaccine (TIV) among pregnant women and determine whether responses differ compared to non-pregnancy.

Methods: Twenty-eight pregnant and 28 non-pregnant women were vaccinated. Serum cytokines were measured at baseline, and 1, 2, and 3 days post-vaccination. Anti-influenza antibody titers were measured at baseline and 1 month post-vaccination.

Results: Overall, following vaccination, tumor necrosis factor (TNF)-α and interleukin(IL)-6 increased significantly, peaking at 1 day post-vaccination (P's < 0.001). Pregnant versus non-pregnant women showed no differences in IL-6, TNF-α, or IL-1β responses. Pregnant women showed no change in IL-8 and increases in migration inhibitory factor (MIF), while non-pregnant showed decreases in both. Pregnancy did not significantly alter antibody responses.

Conclusions: Inflammatory responses to TIV are mild, transient, and generally similar in pregnant and non-pregnant women. Given the variability evidenced, vaccination may provide a useful model for studying individual differences in inflammatory response propensity.

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Figures

Fig 1-5
Fig 1-5
Serum proinflammatory cytokine responses to trivalent influenza virus vaccine (TIV)
See this image and copyright information in PMC

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