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. 2013 May 11;49(38):3985-7.
doi: 10.1039/c3cc39104c. Epub 2013 Apr 4.

QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(IV) prodrug for anticancer applications

Carmen R Maldonado  1 , Nina Gómez-Blanco, Maite Jauregui-Osoro, Valerie G Brunton, Luis Yate, Juan C Mareque-Rivas
Affiliations

QD-filled micelles which combine SPECT and optical imaging with light-induced activation of a platinum(IV) prodrug for anticancer applications

Carmen R Maldonado et al. Chem Commun (Camb). .

Abstract

The fac-[(99m)Tc(OH2)3(CO)3](+) complex reacts with QD-filled micelles to create a bimodal SPECT-optical imaging probe which upon visible light irradiation generates cisplatin from an inert Pt(IV) prodrug.

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