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Review
. 2013 Apr;22(4):400-5.
doi: 10.1177/0961203312469692.

Epratuzumab for systemic lupus erythematosus

D J Wallace  1 , D M Goldenberg
Affiliations
Review

Epratuzumab for systemic lupus erythematosus

D J Wallace et al. Lupus. 2013 Apr.

Abstract

Epratuzumab (EMab, UCB, Immunomedics) is a humanized monoclonal antibody targeting CD22 that is being studied in clinical trials for patients with a variety of rheumatic and hematologic conditions, including systemic lupus erythematosus (SLE). An overview of its mechanism of action is followed by a summary of completed lupus studies, and a preview of studies in progress. The agent clearly has anti-inflammatory activity and is a potentially useful agent in the management of autoimmune disorders.

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