Homer proteins in Ca²⁺ entry
- PMID: 23554128
- DOI: 10.1002/iub.1162
Homer proteins in Ca²⁺ entry
Abstract
The Homer family of proteins consists of three adaptor proteins, Homer1, Homer2 and Homer3, each with various isoforms. Homer1 family presents an EVH1 domain, a coiled coil domain and two leucine zipper domains. Homer proteins regulate a number of Ca2+-handling proteins, including transient receptor potential channels and other Ca2+-permeable channels, ionotropic and metabotropic glutamate receptors, shank scaffolding proteins or endoplasmic reticulum Ca2+ release channels. This review article focuses on the association of Homer 1 proteins with Ca2+-handling proteins and their role on intracellular Ca2+-homeostasis.
Keywords: Homer; IP3R; PMCA; TRP channels.
Copyright © 2013 International Union of Biochemistry and Molecular Biology, Inc.
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