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Review
. 2013 Jun;65(6):497-504.
doi: 10.1002/iub.1162. Epub 2013 Apr 3.

Homer proteins in Ca²⁺ entry

Isaac Jardin  1 , José J López, Alejandro Berna-Erro, Ginés M Salido, Juan A Rosado
Affiliations
Free article
Review

Homer proteins in Ca²⁺ entry

Isaac Jardin et al. IUBMB Life. 2013 Jun.
Free article

Abstract

The Homer family of proteins consists of three adaptor proteins, Homer1, Homer2 and Homer3, each with various isoforms. Homer1 family presents an EVH1 domain, a coiled coil domain and two leucine zipper domains. Homer proteins regulate a number of Ca2+-handling proteins, including transient receptor potential channels and other Ca2+-permeable channels, ionotropic and metabotropic glutamate receptors, shank scaffolding proteins or endoplasmic reticulum Ca2+ release channels. This review article focuses on the association of Homer 1 proteins with Ca2+-handling proteins and their role on intracellular Ca2+-homeostasis.

Keywords: Homer; IP3R; PMCA; TRP channels.

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