Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Jan;25(1):71-3.
doi: 10.1016/S1674-8301(11)60009-2.

Successful conservative management with methotrexate and mifepristone of cervical pregnancy

Eliza Shrestha  1 , Yuebo Yang, Xiaomao Li, Yu Zhang
Affiliations

Successful conservative management with methotrexate and mifepristone of cervical pregnancy

Eliza Shrestha et al. J Biomed Res. 2011 Jan.

Abstract

This study investigated possible effective treatments for cervical pregnancy, a rare form of ectopic pregnancy. The clinical records of 11 cases of ectopic pregnancy admitted to the Third Affiliated Hospital of Sun Yat-sen University from 1998 to 2010 were analyzed. All patients were treated with intermuscular injection of methotrexate (MTX, 50 mg), and oral mifepristone (25 mg, bid). All cases were successfully cured by conservative treatments using methotrexate plus mifepristone. Cervical pregnancy is a contributive factor to mutiple abortions and curettages. Methotrexate plus mifepristone, curettage through hysteroscopy and intracervical obturation with gauze are effective treatments of cervical pregnancy without the need for surgical intervention.

Keywords: cervical pregnancy; conservative treatment; ectopic pregnancy.

PubMed Disclaimer

Conflict of interest statement

The authors reported no conflict of interests.

References

    1. Heikinheimo O, Leminen A, Cacciatore B, Rutanen EM, Kajanoja P. Advanced cervical pregnancy: uterus sparing therapy initiated with a combination of methotrexate and mifepristone followed by evacuation and local hemostatic measures. Acta Obstet Gynecol Scand. 2004;83:211–3. - PubMed
    1. Clarke GL. Cervical pregnancy. Review of the literature and report of a case. Obstet Gynecol. 1960;16:454–8. - PubMed
    1. Shinagawa S, Nagayama M. Cervical pregnancy as a possible sequela of induced abortion. Report of 19 cases. Am J Obstet Gynecol. 1969;105:282–4. - PubMed
    1. Rothe DJ, Birnbaum SJ. Cervical pregnancy: Diagnosis and management. Obstet Gynecol. 1973;42:675–80. - PubMed
    1. Scott JW, Diggory PLC, Edelman PJ. Management of cervical pregnancy with circumsuture and intracervical obturator. Br Med J. 1978;1:825. - PMC - PubMed