Preoperative administration of intramuscular dezocine reduces postoperative pain for laparoscopic cholecystectomy

Abstract

Postoperative pain is the most common complaint after laparoscopic cholecystectomy. This study was carried out to evaluate whether preoperative administration of intramuscular dezocine can provide postoperative analgesia and reduce postoperative opioid consumption in patients undergoing laparoscopic cholecystectomy. Patients (ASA I or II) scheduled for laparoscopic cholecystectomy were randomly assigned into intramuscular dezocine group (group 1) or intramuscular normal saline group (group 2). Dezocine and equal volume normal saline were administered intramuscularly 10 min before the induction of anesthesia. After operation, the severity of postoperative pain, postoperative fentanyl requirement, incidence and severity of side-effects were assessed. Postoperative pain and postoperative patient-controlled fentanyl consumption were reduced significantly in group 1 compared with group 2. The incidence and severity of side effects were similar between the two groups. Preoperative single-dose administration of intramuscular dezocine 0.1 mg/kg was effective in reducing postoperative pain and postoperative patient-controlled fentanyl requirement in patients undergoing laparoscopic cholecystectomy.

Keywords: dezocine; laparoscopic cholecystectomy; postoperative pain.

Fig. 1. Postoperative VAS scores at 0, 4, 8, 12, and 24 h after surgery in two groups.

R2 compared with R1, C2 compared with C1, ^△P < 0.05 and *P < 0.01. VAS: visual analogue scale (0, no pain; 100, worst imaginable pain). R1: VAS scores at rest in group 1. C1: VAS scores during coughing in group 1. R2: VAS scores at rest in group 2. C2: VAS scores during coughing in group 2. Group 1: patients who received intramuscular dezocine. Group 2: patients who received intramuscular saline at an equal volume as dezocine.

Fig. 2. The distribution of patients in the different scales of Ramsay sedation scores of the two groups.

There were no significant differences between group 1 and 2. Ramsay sedation score (1: anxious, agitated, or restless; 2: cooperative, oriented, and tranquil; 3: response to command; 4: brisk response). Group 1: patients who received intramuscular dezocine. Group 2: patients who received intramuscular saline at an equal volume as dezocine.

Fig. 3. The distribution of patients in the different grades of PONV of the two groups.

There were no significant differences between group 1 and 2. PONV: postoperative nausea and vomiting; 0: no nausea or vomiting; 1: mild nausea; 2: moderate nausea; 3: severe nausea with vomiting. Group 1: patients who received intramuscular dezocine. Group 2: patients who received intramuscular saline at an equal volume as dezocine.