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. 2013:2013:132642.
doi: 10.1155/2013/132642. Epub 2013 Mar 11.

Bone-marrow-derived mesenchymal stem cells for organ repair

Ming Li  1 , Susumu Ikehara
Affiliations

Bone-marrow-derived mesenchymal stem cells for organ repair

Ming Li et al. Stem Cells Int. 2013.

Abstract

Mesenchymal stem cells (MSCs) are prototypical adult stem cells with the capacity for self-renewal and differentiation with a broad tissue distribution. MSCs not only differentiate into types of cells of mesodermal lineage but also into endodermal and ectodermal lineages such as bone, fat, cartilage and cardiomyocytes, endothelial cells, lung epithelial cells, hepatocytes, neurons, and pancreatic islets. MSCs have been identified as an adherent, fibroblast-like population and can be isolated from different adult tissues, including bone marrow (BM), umbilical cord, skeletal muscle, and adipose tissue. MSCs secrete factors, including IL-6, M-CSF, IL-10, HGF, and PGE2, that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions. In this paper, we focus on the role of BM-derived MSCs in organ repair.

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Figures

Figure 1
Figure 1
Main actions of BMMSCs.
See this image and copyright information in PMC

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