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. 2013:2013:205208.
doi: 10.1155/2013/205208. Epub 2013 Mar 10.

Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome

Aldo Schenone Giugni  1 , Shylaja Mani, Subramanian Kannan, Betul Hatipoglu
Affiliations

Exophthalmos: A Forgotten Clinical Sign of Cushing's Syndrome

Aldo Schenone Giugni et al. Case Rep Endocrinol. 2013.

Abstract

Exophthalmos is typically associated with Graves' ophthalmopathy. Although originally described by Harvey Cushing, exophthalmos is an underappreciated sign of Cushing's syndrome. We present a case of a 38-year-old female who presented with severe bilateral proptosis and was subsequently diagnosed with Cushings disease. We discuss the possible mechanisms causing exophthalmos in patients with either endogenous or exogenous hypercortisolemia.

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Figures

Figure 1
Figure 1
Bilateral exophthalmos as seen on MRI.
Figure 2
Figure 2
MRI of pituitary (coronal view) (arrows showing the macroadenoma and stalk deviation).
Figure 3
Figure 3
Histology: (a) H&E stain showing basophilic cells at magnification ×200. (b) Positive ACTH staining.
See this image and copyright information in PMC

References

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