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Review
. 2013;8(3):e60153.
doi: 10.1371/journal.pone.0060153. Epub 2013 Mar 21.

Laparoscopic hepatectomy for hepatic colorectal metastases -- a retrospective comparative cohort analysis and literature review

Jianguo Qiu  1 , Shuting Chen, Prasoon Pankaj, Hong Wu
Affiliations
Review

Laparoscopic hepatectomy for hepatic colorectal metastases -- a retrospective comparative cohort analysis and literature review

Jianguo Qiu et al. PLoS One. 2013.

Abstract

Background: Laparoscopic hepatectomy (LH) for management of hepatic colorectal metastases (HCRM) is commonly being performed; however, there are limited reports comparing LH outcomes with those of open hepatectomy (OH) procedure. The aim of the present study was to compare perioperative outcomes between the LH and OH procedures performed at a single medical center.

Methods: From Jan 2008 to May 2012, 30 patients with pathologically confirmed HCRM underwent LH, and 140 patients underwent OH at our hospital. Patients' demographics, perioperative outcomes were retrospectively analyzed.

Results: 2 patients (6.7%) in the LH group underwent laparotomies for intraoperative hemorrhage. The LH group had an increased surgical duration (235 min vs. 365 min, (P<0.001), shorter hospital stay (7.5 days vs. 11.5 days, P<0.001), and fewer complications (26.2% vs. 55%, P<0.001) than the OH group. However, in a matched cohort comparison of 30 LH cases and 30 OH cases, no significant variations were observed in the following parameters: surgical duration (235 min vs. 255 min, P = 0.23), positive margin rates (6.7% vs. 0.0%, P = 0.27), or postoperative hematological changes. LH patients had less estimated blood loss (215 ml vs. 385 ml, P<0.001), less morbidity (26.2% vs. 50%, P = 0.02), shorter hospital stay (7.5 days vs. 11.5 days, P<0.001), and lower analgesic requests than with those in the OH group.

Conclusions: LH for metastatic colorectal cancer is a safe and feasible treatment, even in patients who underwent prior laparotomy surgeries and provides significantly less morbidity and shorter hospital stay than OH, without compromising curability or increasing morbidity.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow chart of attempted hepatectomy.
See this image and copyright information in PMC

References

    1. Sung JJ, Lau JY, Goh KL (2005) Leung WK; Asia Pacific Working Group on Colorectal Cancer (2005) Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol 6: 871–876. - PubMed
    1. Van Cutsem E, Nordlinger B, Adam R, Köhne CH, Pozzo C (2006) et al. Towards a pan-European consensus on the treatment of patients with eolorectal liver metastases. Eur J Cancer 42: 2212–2121. - PubMed
    1. Kitano S, Shiraishi N, Uyama I, Sugihara K, Tanigawa N, et al. (2007) A Multicenter Study on Oncologic Outcome of Laparoscopic Gastrectomy for Early Cancer in Japan. Ann Surg 245: 68–72. - PMC - PubMed
    1. Hewett PJ, Allardyce RA, Bagshaw PF, Frampton CM, Frizelle FA, et al. (2008) Short-Term Outcomes of the Australasian Randomized Clinical Study Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer. Ann Surg 248: 728–738. - PubMed
    1. Johansson M, Thune A, Nelvin L, Stiernstam M, Westman B, et al. (2005) Randomized clinical trial of open versus laparoscopic cholecystectomy in the treatment of acute cholecystitis. Br J Surg 92: 44–49. - PubMed

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