Effects of antithrombin III on glomerulonephritis induced by antibasement membrane antibody in rats

Abstract

Antithrombin III (AT III), a plasma inhibitor of coagulation factors, was evaluated for its inhibitory effects on the development of glomerulonephritis induced by antibasement membrane antibody in rats. AT III was administered intravenously at 250 and 1000 Units/kg to rats once a day for 14 days after intravenous injection of rabbit antiserum against the rat glomerular basement membrane. In the rat model, the high dose of AT III reduced the urinary total protein, plasma total cholesterol and plasma phospholipid, and tended to lower the incidence of fibrin deposits in Bowman's space, cell proliferation in the glomeruli, and PAS-positive granules (absorption droplets) in the glomerular epithelium. The above results suggest that AT III is effective in inhibiting the development of glomerulonephritis.