Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Apr 4:11:96.
doi: 10.1186/1741-7015-11-96.

Phosphodiesterase 4-targeted treatments for autoimmune diseases

Neal Kumar  1 , Ari M Goldminz, Noori Kim, Alice B Gottlieb
Affiliations
Review

Phosphodiesterase 4-targeted treatments for autoimmune diseases

Neal Kumar et al. BMC Med. .

Abstract

Advancements in phosphodiesterase (PDE)-targeted therapies have shown promise in recent years for treating patients with a variety of autoimmune diseases. This review summarizes the development of PDE4 inhibitors and the associated literature with a focus on treatments for autoimmune diseases. After the initial investigations of the prototypic PDE inhibitor, rolipram, more selective inhibitors targeting the PDE4 isozyme have been developed. With phase II and phase III clinical trials currently underway to evaluate the safety and efficacy of the latest generation of PDE4 inhibitors, namely apremilast, a new class of treatments may be around the corner for patients suffering from chronic, autoimmune diseases.

PubMed Disclaimer

References

    1. Sutherland EW, Rall T. The properties of an adenine ribonucleotide produced with cellular particles, ATP, mg, and epinephrine or glucagon. J Am Chem Soc. 1957;79:3608–3608.
    1. Rall T, Sutherland E. Fractionation and characterization of a cyclic adenine ribonucleotide formed by tissue particles. J Biol Chem. 1958;232:1077. - PubMed
    1. Henney CS, Lichtenstein LM. The role of cyclic AMP in the cytolytic activity of lymphocytes. J Immunol. 1971;107:610–612. - PubMed
    1. Henney CS, Bourne HR, Lichtenstein LM. The role of cyclic 3′, 5′ adenosine monophosphate in the specific cytolytic activity of lymphocytes. . J Immunol. 1972;108:1526. - PubMed
    1. Bourne H, Weinstein Y, Melmon K, Lichtenstein L, Henney C, Shearer G. Modulation of inflammation and immunity by cyclic AMP. Science. 1974;184:19–28. doi: 10.1126/science.184.4132.19. - DOI - PubMed

Publication types

MeSH terms