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. 1990 Jul;10(7):3834-7.
doi: 10.1128/mcb.10.7.3834-3837.1990.

Identification of a G1-S-phase-regulated region in the human thymidine kinase gene promoter

H H Roehl  1 , S E Conrad
Affiliations

Identification of a G1-S-phase-regulated region in the human thymidine kinase gene promoter

H H Roehl et al. Mol Cell Biol. 1990 Jul.

Abstract

We have identified a regulatory region in the human thymidine kinase gene promoter. A set of promoter deletion mutants was constructed, linked to the bacterial neomycin resistance gene, and stably transfected into Rat3 cells. It was shown that the region between 135 and 67 base pairs upstream of the cap site is required for conveying G1-S-phase regulation to the linked neo gene. In addition, primer extension assays demonstrated that the same transcriptional start sites were used in G1- and S-phase cells and in the various deletion mutants tested.

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