Relation of distribution of conduction velocities to nerve biopsy findings in n-hexane poisoning

Abstract

Distribution of conduction velocities (DCV) of sensory fibers in sural nerve was investigated in three patients with n-hexane poisoning. Measurements were made at 1-2 months, 4-9 months, and at 11, 23, and 36 months after ending exposure. A sural nerve biopsy was obtained from one of the patients. The results indicated the characteristic changes of n-hexane toxicity: myelinated nerve fiber degeneration and paranodal swelling, resulting in changes in the fiber diameter distribution. The DCV documented these changes. After removal from toxic exposure, varying degrees of recovery were studied clinically and evaluated with nerve conduction parameters. The DCV reflects the pathological changes in nerve in toxic neuropathy due to n-hexane.