Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;7(4):181-90.
doi: 10.4103/1793-5482.106650.

Five-year follow-up results for patients diagnosed with anaplastic astrocytoma and effectiveness of concomitant therapy with temozolomide for recurrent anaplastic astrocytoma

Feyzi Birol Sarica  1 , Melih Cekinmez, Kadir Tufan, Orhan Sen, Huseyin C Onal, Huseyin Mertsoylu, Erkan Topkan, Berrin Pehlivan, Bulent Erdogan, Mehmet N Altinors
Affiliations

Five-year follow-up results for patients diagnosed with anaplastic astrocytoma and effectiveness of concomitant therapy with temozolomide for recurrent anaplastic astrocytoma

Feyzi Birol Sarica et al. Asian J Neurosurg. 2012 Oct.

Abstract

Background: Anaplastic astrocytoma (AA; WHO grade-III) patients determination of prognostic factors helps generating multimodal therapy protocols. For this purpose, in the Baskent University, Adana Medical Research Center, specific characteristics of AA patients who have surgery were retrospectively investigated and factors which affect prognosis has been determined.

Patients and methods: Between January 2005 and 2009, 20 patients who have AA have been evaluated retrospectively. Totally, 20 patients had 31 operations. Sixteen patients had only adjuvant radiation therapy (RT). In the postoperative period, 8 patients received adjuvant RT. Nine of 10 patients with tumor recurrence received concomitant therapy with temozolomide (ConcT with TMZ) protocol. No adjuvant therapy protocol could be applied in three patients with poor general condition in the postoperative period.

Results: Median survival for patients died was 16±17 months; one year survival was 75% and five year survival 25%. After univariate analysis, preoperative Karnofsky performance score (KPS) was ≥80 (P=0.005577(*)), postoperative KPS was ≥80 (P=0.003825(*)), type of tumor resection (P=0.001751(*)), multiple operations (P=0.006233(*)), and ConcT with TMZ protocol (P=0,005766(*)) were all positive prognostic factors which extend the survival.

Conclusions: The results of the multivariate analysis did not put forward an independent prognostic factor acting on the survival period (P>0.05).

Keywords: Anaplastic astrocytoma; concomitant therapy; prognostic factor; recurrence; temozolomide.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Gender and patients’ ages
Figure 2
Figure 2
Logarithm of mean life time for patients who died
Figure 3
Figure 3
Curve of the survival and patients’ gender
Figure 4
Figure 4
Curve of the survival and patients’ age
Figure 5
Figure 5
Curve of the survival and preoperative KPS of patients
Figure 6
Figure 6
Curve of the survival and postoperative KPS of patients
Figure 7
Figure 7
Curve of the survival and localization of tumors
Figure 8
Figure 8
Curve of the survival and largest diameter of tumors
Figure 9
Figure 9
Curve of the survival and subfalcine herniation
Figure 10
Figure 10
Curve of the survival and types of surgical resection of tumors
Figure 11
Figure 11
Curve of the survival and number of operation
Figure 12
Figure 12
Curve of the survival and types of adjuvant therapy
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Giles GG, Gonzales MF. Epidemiology of brain tumors and factors in prognosis. In: Kaye AH, Laws ER Jr, editors. Brain Tumors. 2nd ed. New York: Churchill Livingstone Press; 2001. pp. 51–66.
    1. Stupp R, Reni M, Gatta G, Mazza E, Vecht C. Anaplastic astrocytoma in adults. Crit Rev Oncol Hematol. 2007;63:72–80. - PubMed
    1. Oktar N. Supratentoriyal yuksek dereceli astrositomalar. In: Aksoy K, Palaoglu S, Pamir N, Tuncer R, editors. Temel Norosirurji. 1st ed. Ankara: Turk Norosirurji Dernegi yayinlari; 2005. pp. 653–60.
    1. Stewart LA. Chemotherapy in adult high-grade glioma: A systematic review and meta-analysis of individual patient data from 12 randomised trials. Lancet. 2002;359:1011–8. - PubMed
    1. Stupp R, Gander M, Leyvraz S, Newlands E. Current and future developments in the use of temozolomide for the treatment of brain tumours. Lancet Oncol. 2001;2:552–60. - PubMed