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Case Reports
. 2013:14:34.
doi: 10.11604/pamj.2013.14.34.1778. Epub 2013 Jan 23.

Extramedullary plasmocytoma relapsing at differents sites: an unusual presentation

Maryame Ahnach  1 , Sofia Marouan, Mohamed Rachid, Abdellah Madani, Asmaa Quessar, Said Benchekroun, Meryem Quachouh
Affiliations
Case Reports

Extramedullary plasmocytoma relapsing at differents sites: an unusual presentation

Maryame Ahnach et al. Pan Afr Med J. 2013.

Abstract

Extramedullary plasmacytoma (EMP) is an uncommon plasma cell neoplasm results from plasma cell proliferation and consists of monoclonal plasmacytic infiltration, without bone marrow involvement and any other systemic characteristics of multiple myeloma. EMP accounts for 3% of all plasma cell neoplasms and approximately 80% to 90% of EMP involve submucosa of the upper aerodigestive, while scrotal, dermis and retroperitoneal infiltration are very rare. There are no consensus guidelines for treatment, but EMP is highly radiosensitive, surgery may be considered for some sites, but 11 at 30% can progress in multiple myeloma. We report here an exceptional case of recurrent EMP in much localization. It's about a man 72 years old with initially testicular plasmocytoma who generalized the plasmacytic infiltration after 16 months in skin and progressively in mediastinal and retroperitoneal plasmacytoma, without any medullar and bone involvement.

Keywords: Extramedullary plasmocytoma; primary testicular plasmocytoma; recurrence; retroperitoneal plasmocytoma.

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Figures

Figure 1
Figure 1
Abdominal CT scan showing the retroperitoneal localization
Figure 2
Figure 2
Left:H ex 40 plasmacytoid diffuse proliferation at the biopsy of retroperitoneal soft tissue Right: Immunophenotyping showing an expression of lambda chain
See this image and copyright information in PMC

References

    1. Ooi GC, Chim JC, Au WY, Khong PL. Radiologic manifestations of primary solitary extramedullary and multiple solitary plasmacytomas. Am J Roentgenol. 2002;86:821–827. - PubMed
    1. Majumdar S, Raghavan U, Jones NS. Solitary plasmacytoma and extramedullary plasmacytoma of the paranasal sinuses and soft palate. J Laryngol Otol. 2002;116:962–965. - PubMed
    1. Swerdlow S, Campo E, Harris N, et al. 4th edition 2008. Who classification of tumours of haematopoeitic and lymphoid tissue.
    1. Alexiou C, Kau RJ, Dietztelbinger H, Kremer M, Spiess JC, et al. Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer. 1999;85:2305–2314. - PubMed
    1. Wiltshaw E. The natural history of extramedullary plasmacytoma and its relation to solitary myeloma of bone and myelomatosis. Medicine (Baltimore) 1976;55(3):217–38. - PubMed

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