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Review
. 2013 Aug:47 Suppl 1:93-137.
doi: 10.3109/10715762.2013.792926. Epub 2013 May 7.

Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products

Giancarlo Aldini  1 , Giulio Vistoli, Milan Stefek, N Chondrogianni, Tilman Grune, Jolanta Sereikaite, Izabela Sadowska-Bartosz, Grzegorz Bartosz
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Free article
Review

Molecular strategies to prevent, inhibit, and degrade advanced glycoxidation and advanced lipoxidation end products

Giancarlo Aldini et al. Free Radic Res. 2013 Aug.
Free article

Abstract

The advanced glycoxidation end products (AGEs) and lipoxidation end products (ALEs) contribute to the development of diabetic complications and of other pathologies. The review discusses the possibilities of counteracting the formation and stimulating the degradation of these species by pharmaceuticals and natural compounds. The review discusses inhibitors of ALE and AGE formation, cross-link breakers, ALE/AGE elimination by enzymes and proteolytic systems, receptors for advanced glycation end products (RAGEs) and blockade of the ligand-RAGE axis.

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