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Review
. 2013 Apr;12(4):443-51.
doi: 10.1586/erv.13.19.

The next 10 years for tuberculosis vaccines: do we have the right plans in place?

Joel Meyer  1 , Helen McShane
Affiliations
Review

The next 10 years for tuberculosis vaccines: do we have the right plans in place?

Joel Meyer et al. Expert Rev Vaccines. 2013 Apr.

Abstract

The control of TB is a global health priority. Over the last decade, considerable progress has been made in the field of TB vaccines with numerous vaccine candidates entering the clinic and two candidates now in Phase IIb efficacy trials. Nevertheless, the lack of predictive animal models and biomarkers of TB vaccine efficacy prevents rational vaccine down-selection and necessitates prolonged and expensive clinical efficacy trials in target populations. Advances in molecular technology and progress in the development of human as well as animal mycobacterial challenge models make the identification of one or more immune correlates of protection a genuine prospect over the next decade. Moreover, the increasing pace, extent and coordination of global research efforts in TB promises to broaden understanding and inform the next generation of vaccine candidates against TB as well as related globally important pathogens.

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Figures

Figure 1.
Figure 1.. Cumulative number of novel preventative tuberculosis vaccines in Phase I, IIa and IIb clinical development each year since 2002.
Vaccines no longer in clinical development are included in the data until their year of discontinuation. Vaccines solely being developed for therapeutic indications are excluded.
Figure 2.
Figure 2.. Cumulative and annual number of publications about tuberculosis vaccines each year since 1995.
Publications were counted if they appeared in a PubMed search for terms ‘tuberculosis vaccine’ in either title or abstract for each given year of publication, using the search query (tuberculosis vaccine [Title/Abstract]) AND (‘YYYY’[Date - Publication]). Note that the 2012 figure includes up to end of October 2012.
See this image and copyright information in PMC

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    2. •• This detailed plan outlines a comprehensive strategy for developing and introducing TB vaccines over the next 10 years.

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Websites

    1. WHO Stop TB Partnership Tuberculosis Vaccine Candidates 2011. www.stoptb.org/wg/new_vaccines/assets/documents/TB%20Vaccine%20Pipeline_... (Accessed October 2012)
    1. WHO Global Tuberculosis Control 2011. www.who.int/tb/publications/global_report/2011/gtbr11_full.pdf (Accessed October 2012)
    1. WHO Millennium Development Goals. www.who.int/topics/millennium_development_goals/diseases/en/index.html (Accessed October 2012)
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