doi: 10.1016/0196-9781(90)90073-e.
A cholecystokinin-metabolizing enzyme in rat intestine
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- PMID: 2356152
- DOI: 10.1016/0196-9781(90)90073-e
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A cholecystokinin-metabolizing enzyme in rat intestine
Peptides.
1990 Mar-Apr.
Abstract
Acid extracts of rat intestine contain a material which metabolizes cholecystokinin-33 (CCK-33) to CCK-12. Soybean trypsin inhibitor had little effect on CCK metabolism by the intestinal material. The molecular weight of the CCK-metabolizing activity, estimated by gel filtration, was 34,000. These data suggest rat intestine contains a nontrypsin CCK-metabolizing enzyme. Results from gel filtration also suggest that large CCK forms can be artifactually degraded to smaller ones during chromatography.
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