Insulin and ventral tegmental dopamine: what's impaired and what's intact?
- PMID: 23562071
- DOI: 10.1016/j.cmet.2013.03.011
Insulin and ventral tegmental dopamine: what's impaired and what's intact?
Abstract
Manipulations affecting mesolimbic dopamine transmission exert specific effects on normal and pathological aspects of motivation, altering some functions while sparing others. Labouèbe et al. (2013) show that insulin induced long-term depression in ventral tegmental neurons, which was associated with reduced responsiveness to food-related stimuli but spared aspects of food-seeking behavior.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids.Nat Neurosci. 2013 Mar;16(3):300-8. doi: 10.1038/nn.3321. Epub 2013 Jan 27. Nat Neurosci. 2013. PMID: 23354329 Free PMC article.
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