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Review
. 2013 Apr;3(2):217-24.
doi: 10.1016/j.coviro.2013.03.001. Epub 2013 Apr 4.

Intervention strategies for emerging viruses: use of antivirals

Yannick Debing  1 , Dirk Jochmans, Johan Neyts
Affiliations
Review

Intervention strategies for emerging viruses: use of antivirals

Yannick Debing et al. Curr Opin Virol. 2013 Apr.

Abstract

Today, small molecule antiviral drugs are available for the treatment of infections with herpesviruses, HIV, HBV and HCV as well as with influenza viruses. Ribavirin, a broad-spectrum (but aspecific) antiviral, has been approved for the treatment of infections with respiratory syncytial virus, HCV and Lassa virus. Yet, for many other viruses that cause life-threatening infections [most of which are considered emerging and/or neglected] there are no drugs available. Ideally, potent and broad-spectrum (i.e., pan-genus or pan-family virus activity) antiviral drugs should be developed whereby one drug could be used for the treatment of a number of such viral infections. We here review recent evolutions in the search for inhibitors of emerging and neglected RNA viruses.

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