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. 2013 May 21;13(10):1963-8.
doi: 10.1039/c3lc50302j. Epub 2013 Apr 5.

Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood

Zheng Zhang  1 , Jeffrey Borenstein, Linda Guiney, Raanan Miller, Sivaprasad Sukavaneshvar, Christopher Loose
Affiliations

Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood

Zheng Zhang et al. Lab Chip. .

Abstract

Assembled polydimethylsiloxane microfluidic devices were modified with a sulfobetaine polymer through continuous "tip-to-tip" modification, significantly reducing blood clotting and extending device patency under blood flow. This technology can be designed to enable the development of devices that can continuously work in whole blood, especially in an extracorporeal or in vivo environment.

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