Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2013 Aug;21(4):352-7.
doi: 10.1177/1066896913482729. Epub 2013 Apr 5.

Comparison of biochemical recurrence-free survival between periprostatic and pelvic lymph node metastases of prostate cancer

Nilda González-Roibón  1 , Jeong S Han, Stephen Lee, Zhaoyong Feng, Sehbal Arslankoz, Nathaniel Smith, Philip M Pierorazio, Elizabeth Humphreys, Theodore L Deweese, Alan W Partin, Trinity J Bivalacqua, Misop Han, Bruce Trock, Georges J Netto
Affiliations
Comparative Study

Comparison of biochemical recurrence-free survival between periprostatic and pelvic lymph node metastases of prostate cancer

Nilda González-Roibón et al. Int J Surg Pathol. 2013 Aug.

Abstract

Objective: To assess the pathologic characteristics and prognostic significance of periprostatic lymph node (LN) metastasis of prostate cancer. The latter was performed by comparing biochemical recurrence (BCR)-free survival in cases of periprostatic LN metastasis versus matched patients showing pelvic LN metastasis.

Methods and materials: We identified 15 patients who underwent radical prostatectomy in our institution (1984-2011) showing positive periprostatic and negative pelvic LN with available follow-up information (group 1). These patients were matched 1:2 to patients with positive pelvic LN (group 2) for pertinent clinicopathologic parameters.

Results: Main locations of positive periprostatic LN were posterior base and mid posterolateral. Overall higher rate of positive margins, smaller LN, and metastasis size were encountered in group 1 compared with group 2. At 5 years postprostatectomy, 69% of patients in group 1 were free of BCR, whereas 26% of those in group 2 remained BCR free, suggesting that patients with periprostatic node metastasis appeared to have a lower risk of BCR. However, the difference was not statistically significant (P = .072). The same was true when adjusted for the effect of prostate-specific antigen, surgical margin status, size of LNs, size of metastasis, age, and year of surgery.

Conclusion: Patients with periprostatic node metastasis may have a lower risk of BCR compared with those with metastasis to pelvic LN. Future analysis of larger cohorts will help establish the biologic significance of prostate cancer metastasis to periprostatic LN.

Keywords: biochemical recurrence; metastasis; periprostatic lymph node; prostate cancer; prostatectomy.

PubMed Disclaimer

Conflict of interest statement

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1
Figure 1
Kaplan–Meier biochemical recurrence (BCR)–free survival estimates in patients with metastasis to periprostatic (group 1) and pelvic (group 2) lymph nodes. All recurrences in group 1 occurred within 1 year. At 5 years after surgery, 69% of patients in group 1 were free of BCR whereas 26% of those in group 2 remained free of BCR at that time.
See this image and copyright information in PMC

References

    1. Adams J, Cheng L. Lymph node-positive prostate cancer: current issues, emerging technology and impact on clinical outcome. Expert Rev Anticancer Ther. 2011;11:1457–1469. - PubMed
    1. Kothari PS, Scardino PT, Ohori M, Kattan MW, Wheeler TM. Incidence, location, and significance of periprostatic and periseminal vesicle lymph nodes in prostate cancer. Am J Surg Pathol. 2001;25:1429–1432. - PubMed
    1. Deng FM, Mendrinos SE, Das K, Melamed J. Periprostatic lymph node metastasis in prostate cancer and its clinical significance. Histopathology. 2012;60:1004–1008. - PubMed
    1. Subik MK, Yao JL, di Sant’Agnese PA, Miyamoto H. The role of periprostatic and periseminal vesicle lymph node metastasis in the staging and prognosis of prostate cancer. Histopathology. 2012;60:1009–1010. - PubMed
    1. Lin DY, Wei LJ. The robust inference for the proportional hazards model. J Am Stat Assoc. 1989;84:1074–1078.

Publication types

Substances