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. 2012 Dec;16(Suppl 2):S162-6.
doi: 10.4103/2230-8210.104030.

Promise and pitfalls of molecular markers of thyroid nodules

S Jadhav  1 , Anurag Lila, Tushar Bandgar, Nalini Shah
Affiliations

Promise and pitfalls of molecular markers of thyroid nodules

S Jadhav et al. Indian J Endocrinol Metab. 2012 Dec.

Abstract

Thyroid nodules are common in the general population with a prevalence of 5-7% The initial evaluation of thyroid nodules commonly involves thyroid function tests, an ultrasound (USG) and fine needle aspiration biopsy (FNAB). The optimal management of patients with thyroid nodules with indeterminate cytology is plagued by the lack of highly sensitive and specific diagnostic modalities In this article we attempt to review the available literature on the molecular markers which are increasingly being studied for their diagnostic utility in assessing thyroid nodules. The various molecular markers consist of gene mutations, gene re arrangements, RNA based assays and immunohistochemical markers. The molecular markers definitely would help to optimise the management of such patients.

Keywords: Molecular markers; gene rearrangements; genetic mutations; thyroid nodules.

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Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Algorithm for approach to thyroid nodules with molecular markers
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References

    1. Gharib H, Papini E, Paschke R, Duick DS, Valcavi R, Hegedus L, et al. American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules. Endocr Pract. 2010;16(Suppl1):468–75. - PubMed
    1. Piana S, Frasoldati A, Ferrari M, Valcavi R, Froio E, Barbieri V, et al. Is a five-category reporting scheme for thyroid fine needle aspiration cytology accurate? Experience of over 18,000 FNAs reported at the same institution during 1998–2007. Cytopathology. 2011;22:164–73. - PubMed
    1. Hassell LA, Gillies EM, Dunn ST. Cytologic and molecular diagnosis of thyroid cancers cancer. Cancer Cytopathol. 2012;120:7–17. - PubMed
    1. Kim MI, Alexander EK. Diagnostic use of molecular markers in the evaluation of thyroid nodules. Endocr Pract. 2012;18:796–802. - PubMed
    1. Lupi C, Giannini R, Ugolini C, Proietti A, Berti P, Minuto M, et al. Association of BRAF V600E mutation with poor clinicopathologic outcomes in 500 consecutive cases of papillary thyroid carcinoma. J Clin Endocrinol Metab. 2007;92:4085–90. - PubMed