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. 2013 Apr 19;15(8):1890-3.
doi: 10.1021/ol400542b. Epub 2013 Apr 8.

Synthesis and reactivity of unsymmetrical azomethine imines formed using alkene aminocarbonylation

Wei Gan  1 , Patrick J Moon, Christian Clavette, Nicolas Das Neves, Thomas Markiewicz, Amy B Toderian, André M Beauchemin
Affiliations

Synthesis and reactivity of unsymmetrical azomethine imines formed using alkene aminocarbonylation

Wei Gan et al. Org Lett. .

Abstract

Complex cyclic azomethine imines possessing a β-aminocarbonyl motif can be accessed readily from simple alkenes and hydrazones. This alkene aminocarbonylation approach allows formation of ketone-derived azomethine imines of unprecedented complexity. Since unsymmetrical hydrazones are used, two stereoisomers are formed: the reactivity of chiral derivatives is explored in both intra- and intermolecular systems.

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